We built the experimental system which involve high concentration of neutral
cosolutes and we evaluated quantitatively for the effect of environment
on the biomolecular. We built up the database by summarizing these information.
However, these system absolutely molecular crowding condition which is
homogeneous. Intracell is the condition not only existing high concentration
of molecules but also highly comparted by lipid membrane and huge structure
which consists of biomolecular (for example, chromatin or cytoskelton).
We call heterogeneous molecular crowding condition like this, "Organizational
Crowding”. Biosis make transcription from DNA and translation from mRNA.
These systems are regulated by molecular crowding which changes dynamic.We
perform the analysis that considered spatial-temporal crowding dynamics.
... |
