| Quantitative analysis for the interactions between nucleic acids
and proteins based on the effect of solvation energy ～To create novel functional nucleic acids ～ |
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| It would not be an exaggeration to say that the biological systems in cells are orchestrated by the network of interactions between nucleic acids and proteins. In addition, the stabilities and structures of nucleic acids are affected significantly by the changing of molecular environments such as concentration of cations and water activity. Therefore, we study the effect of solvation energy on the specificity and selectivity of interactions between nucleic acids and proteins based on a physicochemical analysis. From the thermodynamic and kinetic information, we will reveal biomolecular interaction systems in cells and try to create novel functional nucleic acids to regulate the biological systems. | ||
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